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The influence of the gut microbiota on the bioavailability of oral drugs.

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第一作者: Xintong,Zhang
第一单位: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
作者: Xintong,Zhang [1] ; Ying,Han [1] ; Wei,Huang [1] ; Mingji,Jin [1] ; Zhonggao,Gao [1]
作者单位: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. [1]
关键词 5-ASA, 5-aminosalicylic acidAA, ascorbic acidABC, ATP-binding cassetteACS, amphipathic chitosan derivativeAMI, amiodaroneAQP4, aquaporin 4AR, azoreductaseASP, amisulprideBBR, berberineBCRP, breast cancer resistance proteinBCS, biopharmaceutics classification systemBDDCS, the biopharmaceutics drug disposition classification systemBDEPT, the bacteria-directed enzyme prodrug therapyBSH, bile salt hydrolaseBioavailabilityCA, cholic acidCDCA, chenodeoxycholic acidCPP, cell-penetrating peptideCS, chitosanColon-specific drug delivery systemDCA, deoxycholic acidDRPs, digoxin reduction productsEcN, Escherichia coli Nissle 1917FA, folateFAO, Food and Agriculture Organization of the United NationsGCDC, glycochenodeoxycholateGL, glycyrrhizic acidGut microbiotaHFD, high fat dietHTC, hematocritIBD, inflammatory bowel diseaseLCA, lithocholic acidLPS, lipopolysaccharideMATEs, multidrug and toxin extrusion proteinsMDR1, multidrug resistance gene 1MDR1a, multidrug resistance protein-1aMKC, monoketocholic acidMPA, mycophenolic acidMRP2, multidrug resistance-associated protein 2NEC, necrotizing enterocolitisNMEs, new molecular entitiesNRs, nitroreductasesNSAIDs, non-steroidal anti-inflammatory drugsNaDC, sodium deoxycholateNaGC, sodium glycholateOATs, organic anion transportersOCTNs, organic zwitterion/cationOCTs, organic cation transportersOral drugsP-gp, P-glycoproteinPD, Parkinson's diseasePPIs, proton pump inhibitorsPT, pectinPWSDs, poorly water-soluble drugsProbioticsRA, rheumatoid arthritisRBC, red blood cellSCFAs, short-chain fatty acidsSGLT-1, sodium-coupled glucose transporter 1SLC, solute carrierSLN, solid lipid nanoparticleSP, sulfapyridineSSZ, sulfasalazineSVCT-1/2, the sodium-dependent vitamin C transporter-1/2T1D, type 1 diabetesT1DM, type 1 diabetes mellitusT2D, type 2 diabetesTCA, taurocholateTCDC, taurochenodeoxycholateTDCA, taurodeoxycholateTLCA, taurolithocholateTME, the tumor microenvironmentUDC, ursodeoxycholic acidWHO, World Health Organizationan OTC drug, an over-the-counter drugcgr operon, cardiac glycoside reductase operondhBBR, dihydroberberinepKa, dissociation constantthe GI tract, the gastrointestinal tract
DOI 10.1016/j.apsb.2020.09.013
PMID 34386321
发布时间 2023-11-07
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Acta pharmaceutica Sinica. B

Acta pharmaceutica Sinica. B

2021年11卷7期

1789-1812页

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