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Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence.

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第一作者: Yingying,Zhang
第一单位: School of Life Sciences, Tianjin University, Tianjin 300072, China.;Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin 300072, China.
作者: Yingying,Zhang [1] ; Tiange,Wang [1] ; Yu,Tian [1] ; Chaonan,Zhang [1] ; Kun,Ge [2] ; Jinchao,Zhang [2] ; Jin,Chang [1] ; Hanjie,Wang [1]
作者单位: School of Life Sciences, Tianjin University, Tianjin 300072, China.;Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin 300072, China. [1] College of Chemistry & Environmental Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China. [2]
关键词 AFP, alpha fetoproteinAP1-QDs, CEA aptamer-modified CdTe QDsAP2-AuNRs, CEA aptamer-modified AuNRsAP2-AuNRs, and interferon-γAgNO3, silver nitrateAuNRs, gold nanorodsCA, cancer antigenCEA, carcinoembryonic antigenCTAB, cetrimonium bromideCTCs, circulating tumor cellsCarcinoembryonic antigenCdCl2, cadmium chlorideCdTe QDs, CdTe quantum dotsDC, dendritic cellsDLS, dynamic light scatteringEDC, 1-ethyl-3-(3′-dimethylaminopropyl) carbodiimideFBS, fetal bovine serumFRET, fluorescence resonance energy transferFluorescence resonance energy transferGSH, glutathioneGold nanorodsHAuCl4, gold chlorideHelf, human embryonic lung fibroblasts linesHydrogel+IFN-γ+QA, thermal responsive hydrogels co-loaded with AP1-QDsHydrogel+IFN-γ, thermal responsive hydrogels loaded with interferon-γICG, indocyanine greenIFN-γ, interferon-γIR, infraredLA+NIR, liposomes encapsulated AuNRs with near-infrared irradiationLA, liposomes encapsulated AuNRsLAI, liposomes loaded with ICG and encapsulated AuNRsLLC, murine lung cancer cellsLung metastasisMTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideNHS, N-hydroxysuccinimideNIR, near-infrared irradiationNaBH4, sodium borohydrideNaHTe, sodium hydrogen telluridePD1, programmed cell death protein 1PDL1, programmed cell death-ligand 1PI, propidium iodidePLGA-PEG-PLGA, thermal responsive hydrogelPTT, photothermal therapyPhototherapyPost-surgical tumor recurrenceQDs, quantum dotsSynergistic immunotherapyTEM, transmission electron microscopeTheranosticsaPDL1-LA+NIR, anti-PDL1-modified liposomes encapsulated AuNRs with near-infrared irradiationaPDL1-LA, anti-PDL1-modified liposomes encapsulated AuNRsaPDL1-LAI, anti-PDL1-modified liposomes loaded with ICG and encapsulated AuNRsanti-PDL1, anti-programmed cell death-ligand 1
DOI 10.1016/j.apsb.2021.03.035
PMID 34386332
发布时间 2021-08-14
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Acta pharmaceutica Sinica. B

Acta pharmaceutica Sinica. B

2021年11卷7期

1978-1992页

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