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Single paternal dexamethasone challenge programs offspring metabolism and reveals multiple candidates in RNA-mediated inheritance.

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第一作者： Katharina,Gapp

第一单位： Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK.;Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.;Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zürich, Zürich, 8057, Switzerland.;Neuroscience Center Zurich, ETH Zurich and University of Zurich, Zürich, 8057, Switzerland.

作者： Katharina,Gapp ^[1] ; Guillermo E,Parada ^[2] ; Fridolin,Gross ^[3] ; Alberto,Corcoba ^[4] ; Jasmine,Kaur ^[3] ; Evelyn,Grau ^[5] ; Martin,Hemberg ^[6] ; Johannes,Bohacek ^[7] ; Eric A,Miska ^[2]

作者单位： Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK.;Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.;Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zürich, Zürich, 8057, Switzerland.;Neuroscience Center Zurich, ETH Zurich and University of Zurich, Zürich, 8057, Switzerland. ^[1] Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK.;Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.;Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK. ^[2] Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zürich, Zürich, 8057, Switzerland. ^[3] Wellcome Sanger Institute, Hinxton, CB10 1SA, UK. ^[4] Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.;Department of Medicine, CITIID, University of Cambridge, Cambridge CB2 0AW, UK. ^[5] Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK.;Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.;Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02215, USA. ^[6] Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zürich, Zürich, 8057, Switzerland.;Neuroscience Center Zurich, ETH Zurich and University of Zurich, Zürich, 8057, Switzerland. ^[7]

关键词 Developmental biology Embryology Molecular physiology Transcriptomics

DOI 10.1016/j.isci.2021.102870

PMID 34386731

发布时间 2026-04-09

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