Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.-论文-万方医学网

第一作者： Tom D,Heightman

第一单位： Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.

作者： Tom D,Heightman ^[1] ; Valerio,Berdini ^[1] ; Luke,Bevan ^[1] ; Ildiko M,Buck ^[1] ; Maria G,Carr ^[1] ; Aurélie,Courtin ^[1] ; Joseph E,Coyle ^[1] ; James E H,Day ^[1] ; Charlotte,East ^[1] ; Lynsey,Fazal ^[1] ; Charlotte M,Griffiths-Jones ^[1] ; Steven,Howard ^[1] ; Justyna,Kucia-Tran ^[1] ; Vanessa,Martins ^[1] ; Sandra,Muench ^[1] ; Joanne M,Munck ^[1] ; David,Norton ^[1] ; Marc,O'Reilly ^[1] ; Nicholas,Palmer ^[1] ; Puja,Pathuri ^[1] ; Torren M,Peakman ^[1] ; Michael,Reader ^[1] ; David C,Rees ^[1] ; Sharna J,Rich ^[1] ; Alpesh,Shah ^[1] ; Nicola G,Wallis ^[1] ; Hugh,Walton ^[1] ; Nicola E,Wilsher ^[1] ; Alison J-A,Woolford ^[1] ; Michael,Cooke ^[2] ; David,Cousin ^[2] ; Stuart,Onions ^[2] ; Jonathan,Shannon ^[2] ; John,Watts ^[2] ; Christopher W,Murray ^[1]

作者单位： Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K. ^[1] Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham NG1 1GF, U.K. ^[2]

医学主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);结晶学, X线(Crystallography, X-Ray);狗(Dogs);人类(Humans);吲哚类(Indoles);男(雄)性(Male);小鼠, 近交BALB C(Mice, Inbred BALB C);丝裂原活化蛋白激酶1(Mitogen-Activated Protein Kinase 1);分子结构(Molecular Structure);肿瘤(Neoplasms);磷酰化(Phosphorylation);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);嘧啶类(Pyrimidines);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);大鼠, Wistar(Rats, Wistar);构效关系(Structure-Activity Relationship);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);小鼠(Mice);大鼠(Rats)

DOI 10.1021/acs.jmedchem.1c00905

PMID 34387469

发布时间 2024-02-26

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Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.

Journal of medicinal chemistry

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Journal of medicinal chemistry

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Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.

Journal of medicinal chemistry

相似文献

同项目论文

Journal of medicinal chemistry

相关期刊

检索历史清除