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Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi.

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第一作者： Wenbo,Yin

第一单位： Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.

作者： Wenbo,Yin ^[1] ; Yuxin,Zhang ^[1] ; Hengxian,Cui ^[1] ; Hong,Jiang ^[1] ; Lei,Liu ^[1] ; Yang,Zheng ^[1] ; Tianxiao,Wu ^[1] ; Liyu,Zhao ^[1] ; Yin,Sun ^[1] ; Xin,Su ^[2] ; Song,Li ^[3] ; Dongmei,Zhao ^[4] ; Maosheng,Cheng ^[1]

作者单位： Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. ^[1] The School of Life Science and Biopharmaceutical, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. ^[2] Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: lis.lisong@gmail.com. ^[3] Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: medchemzhao@163.com. ^[4]

关键词 Azole antifungals CYP51 Fluconazole-resistance Fungicidal agents