Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples.

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第一作者： Susan,Klaeger

第一单位： Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. Electronic address: sklaeger@broadinstitute.org.

作者： Susan,Klaeger ^[1] ; Annie,Apffel ^[2] ; Karl R,Clauser ^[2] ; Siranush,Sarkizova ^[2] ; Giacomo,Oliveira ^[3] ; Suzanna,Rachimi ^[2] ; Phuong M,Le ^[4] ; Anna,Tarren ^[4] ; Vipheaviny,Chea ^[4] ; Jennifer G,Abelin ^[2] ; David A,Braun ^[5] ; Patrick A,Ott ^[5] ; Hasmik,Keshishian ^[2] ; Nir,Hacohen ^[6] ; Derin B,Keskin ^[7] ; Catherine J,Wu ^[5] ; Steven A,Carr ^[8]

作者单位： Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. Electronic address: sklaeger@broadinstitute.org. ^[1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. ^[2] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. ^[3] Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. ^[4] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. ^[5] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA. ^[6] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Health Informatics Lab, Metropolitan College, Boston University, Boston, Massachusetts, USA. ^[7] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. Electronic address: scarr@broad.mit.edu. ^[8]

关键词 FAIMS HLA basic reversed-phase fractionation immunopeptidomics ion mobility