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A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma.

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第一作者： Clayton S,Lewis

第一单位： Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

作者： Clayton S,Lewis ^[1] ; Aniruddha,Karve ^[2] ; Kateryna,Matiash ^[1] ; Timothy,Stone ^[3] ; Jingxing,Li ^[4] ; Jordon K,Wang ^[4] ; Henri H,Versteeg ^[5] ; Bruce J,Aronow ^[6] ; Syed A,Ahmad ^[7] ; Pankaj B,Desai ^[2] ; Vladimir Y,Bogdanov ^[1]

作者单位： Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States. ^[1] Division of Pharmaceutical Sciences, University of Cincinnati College of Pharmacy, Cincinnati, OH, United States. ^[2] Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, United States. ^[3] Technology Development, LakePharma, Inc., Belmont, CA, United States. ^[4] Einthoven Laboratory for Experimental Vascular Medicine, Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands. ^[5] Department of Biomedical Informatics, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, United States. ^[6] Division of Surgical Oncology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States. ^[7]

关键词 alternative splicing monoclonal antibodies orthotopic tumor model pancreatic ductal adenocarcinoma tissue factor

DOI 10.3389/fonc.2021.691685

PMID 34395257

发布时间 2021-10-13

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