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Acetylation of the Catalytic Lysine Inhibits Kinase Activity in PI3Kδ.

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第一作者： Julie C L,Fournier

第一单位： GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.;Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.

作者： Julie C L,Fournier ^[1] ; John P,Evans ^[2] ; Francesca,Zappacosta ^[3] ; Daniel A,Thomas ^[2] ; Vipulkumar K,Patel ^[4] ; Gemma V,White ^[4] ; Sebastien,Campos ^[5] ; Nicholas C O,Tomkinson ^[6]

作者单位： GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.;Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom. ^[1] Arctoris, 120E Olympic Avenue, Milton Park, Oxford, OX14 4SA, United Kingdom. ^[2] GSK, South Collegeville Road, Collegeville, Pennsylvania 19426, United States. ^[3] GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom. ^[4] Pharmaron, West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire EN11 9FH, United Kingdom. ^[5] Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom. ^[6]