Model studies towards prodrugs of the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) containing a diazo precursor.

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第一作者： Run-Duo,Gao

第一单位： Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD 21205, USA.

作者： Run-Duo,Gao ^[1] ; Niyada,Hin ^[2] ; Eva,Prchalová ^[1] ; Arindom,Pal ^[1] ; Jenny,Lam ^[3] ; Rana,Rais ^[1] ; Barbara S,Slusher ^[1] ; Takashi,Tsukamoto ^[4]

作者单位： Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD 21205, USA. ^[1] Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA. ^[2] Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD 21205, USA. ^[3] Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA; Johns Hopkins Drug Discovery, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: ttsukamoto@jhmi.edu. ^[4]

关键词 6-Diazo-5-oxo-l-norleucine Prodrug α-Diazoketone

主题词重氮亮氨酸(Diazooxonorleucine);药物设计(Drug Design);药物稳定性(Drug Stability);谷氨酰胺(Glutamine);分子结构(Molecular Structure);药物前体(Prodrugs)

DOI 10.1016/j.bmcl.2021.128321

PMID 34400301

发布时间 2022-10-16

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