第一单位：
Postgraduate Program in Pharmaceutical Innovation, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.
作者：
Antonio Rafael,Quadros Gomes [1]
;
Natasha Costa,da Rocha Galucio [2]
;
Kelly Cristina Oliveira,de Albuquerque [3]
;
Heliton Patrick Cordovil,Brígido [1]
;
Everton Luiz Pompeu,Varela [4]
;
Ana Laura Gadelha,Castro [5]
;
Valdicley Vieira,Vale [1]
;
Marcelo Oliveira,Bahia [6]
;
Rommel Mario,Rodriguez Burbano [7]
;
Fábio Alberto,de Molfeta [8]
;
Liliane Almeida,Carneiro [9]
;
Sandro,Percario [4]
;
Maria Fâni,Dolabela [10]
作者单位：
Postgraduate Program in Pharmaceutical Innovation, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.
[1]
Postgraduate Program in Genetics and Molecular Biology, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.;Postgraduate Program in Pharmaceutical Sciences, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.
[2]
Postgraduate Program in Biodiversity and Biotechnology, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.
[3]
Postgraduate Program in Biodiversity and Biotechnology, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.;Oxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.
[4]
Postgraduate Program in Genetics and Molecular Biology, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.
[5]
Postgraduate Program in Neuroscience and Cell Biology, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.
[6]
Postgraduate Program in Genetics and Molecular Biology, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.;Postgraduate Program in Neuroscience and Cell Biology, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.
[7]
Postgraduate Program in Chemistry, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.
[8]
National Primate Center, Rodovia Br 316, Km. 7, 67.030-000, Ananindeua, PA, Brazil.
[9]
Postgraduate Program in Pharmaceutical Innovation, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.;Postgraduate Program in Pharmaceutical Sciences, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.;Postgraduate Program in Biodiversity and Biotechnology, Federal University of Pará, Av. Augusto Corrêa, 1, Guamá, 66075-110, Belém, PA, Brazil.
[10]
关键词
ALT, alanine aminotransferaseAST, aspartate aminotransferaseBCRJ, Cell bank of Rio de JaneiroBFS, bovine fetal serumCaspase-8DARP, dopamine releasing proteinDMEM, Dulbecco's Modified Eagle's MediumDMSO, dimethyl sulfoxideDPPH, 2,2-diphenyl-1-picrylhydrazylEDTA, ethylenediaminetetraaceticEEEp, ethanol extract of Eleutherine plicataEleutherinEleutherine plicataEleutherolFADD, Fas associated death domainFDMEp, dichloromethane fraction of Eleutherine plicataFrAE, ethyl acetate fraction of Elutherine plicataGA, Genetic AlgorithmGOLD, Genetic Optimization for Ligand DockingHPLC, high performance liquid chromatographyIC50, 50 cytotoxic concentrationIsoeleutherinMD, molecular dynamicsMTT, ([3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide])NMR, nuclear magnetic resonanceNMU, N-methyl-N-nitrosureaOECD, Organization for Economic Co-Operation and DevelopmentPDB, Protein Data BankROS, reactive oxygen speciesRPMI, Roswell Park Memorial Institute mediumRSMD, root mean square deviationTLC, tin layer chromatographyTNFR, tumour necrosis fator receptorToxicityrpm, rotations per minute
DOI
10.1016/j.toxrep.2021.07.015
PMID
34401358
发布时间
2021-08-18
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