Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere.

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第一作者： Julius,Bogomolovas

第一单位： Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA.

作者： Julius,Bogomolovas ^[1] ; Jennifer R,Fleming ^[2] ; Barbara,Franke ^[3] ; Bruno,Manso ^[4] ; Bernd,Simon ^[4] ; Alexander,Gasch ^[4] ; Marija,Markovic ^[5] ; Thomas,Brunner ^[3] ; Ralph,Knöll ^[4] ; Ju,Chen ^[4] ; Siegfried,Labeit ^[6] ; Martin,Scheffner ^[7] ; Christine,Peter ^[1] ; Olga,Mayans ^[3]

作者单位： Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA. ^[1] Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. ^[2] Department of Integrative Pathophysiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. ^[3] Department of Biology, University of Konstanz, Konstanz, Germany. ^[4] Structural and Computational Biology Unit, EMBL, Heidelberg, Germany. ^[5] Integrated Cardio Metabolic Centre (ICMC), Heart and Vascular Theme, University Hospital, MedH, Karolinska Institutet, Huddinge, Sweden. ^[6] Bioscience, Cardiovascular, Renal & Metabolism, BioPharmaceuticals, R&D, AstraZeneca, Gothenburg, Sweden. ^[7] Department of Chemistry, University of Konstanz, Konstanz, Germany. ^[8]

关键词 X-ray crystallography cellular signalling mechanotransduction steered molecular dynamics simulations ubiquitination

主题词自噬(Autophagy);肌, 骨骼(Muscle, Skeletal);肌节(Sarcomeres);泛素化(Ubiquitination)

DOI 10.15252/embr.201948018

PMID 34402565

发布时间 2024-06-08

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