CRISPR/Cas9-mediated gene editing on Sox2ot promoter leads to its truncated expression and does not influence neural tube closure and embryonic development in mice.

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作者： Pu-Yu,Li ^[1] ; San-Qiang,Li ^[2] ; She-Gan,Gao ^[3] ; Dao-Yin,Dong ^[4]

作者单位： Department of General Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, 471000, China. ^[1] Henan Centre for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, College of Basic Medicine, Henan University of Science and Technology, Luoyang, 471000, China. ^[2] Henan Key Laboratory of Cancer Epigenetics, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, 471000, China. ^[3] Department of Public Health, College of Basic Medicine, Henan University of Science and Technology, Luoyang, 471000, China. Electronic address: dongdy@haust.edu.cn. ^[4]

关键词 CRISPR/Cas9 Embryonic development Neural tube closure Promoter Sox2ot

主题词动物(Animals);胚胎发育(Embryonic Development);小鼠(Mice);神经管(Neural Tube);启动区, 遗传(Promoter Regions, Genetic)

DOI 10.1016/j.bbrc.2021.08.029

PMID 34403806

发布时间 2021-11-18

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准确一般字义偏差语意偏离译文作用小提交