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DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death.

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作者单位: Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Rome, Italy. stefano.bonassi@sanraffaele.it. [1] Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Via di Val Cannuta, 247, 00166, Rome, Italy. stefano.bonassi@sanraffaele.it. [2] Clinical Epidemiology Unit, San Martino Policlinic Hospital, Genoa, Italy. [3] Department of Public Health, Section of Environmental Health, University of Copenhagen, Oster Farimagsgade 5A, 1014, Copenhagen, Denmark. [4] Department of Pharmacology and Toxicology, University of Navarra, C/Irunlarrea 1, 31008, Pamplona, Spain. [5] C/Irunlarrea 3, IdiSNA, Navarra Institute for Health Research, 31008, Pamplona, Spain. [6] Mutagenesis Unit, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000, Zagreb, Croatia. [7] Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Rome, Italy. [8] Department of Environmental Health, Section of Molecular Toxicology, Norwegian Institute of Public Health (NIPH), Lovisenberggt 6, 0456, Oslo, Norway. [9] Department of Pharmacology and Toxicology, School of Nutrition and Translational Research in Metabolism, University of Maastricht, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands. [10] Flemish Institute of Technological Research, Environmental Risk and Health Unit VITO - BIOMo, Mol, Belgium. [11] Environmental Health Department, National Institute of Health, Rua Alexandre Herculano, 321, 4000-055, Porto, Portugal. [12] Environmental Health Department, Instituto Nacional de Saúde Doutor Ricardo Jorge, Rua Alexandre Herculano 321, 4000-055, Porto, Portugal. [13] EPIUnit - Instituto de Saúde Pública, Universidade Do Porto, Rua das Taipas, no 135, 4050-600, Porto, Portugal. [14] Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA), and La Salle University (UNILASALLE), Canoas, RS, Brazil. [15] Department of Occupational and Environmental Medicine, Epidemiology and Hygiene (DiMEILA), Italian Workers' Compensation Authority (INAIL), Via Fontana Candida 1, 00078, Monte Porzio Catone (Rome), Italy. [16] Department NEUROFARBA, University of Florence, Viale G. Pieraccini 6, 50139, Florence, Italy. [17] Department of Health Sciences, Division of Dermatology, University of Florence, Palagi Hospital, Viale Michelangelo 41, Florence, Italy. [18] Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Celoria 2, 20133, Milan, Italy. [19] Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Via di Val Cannuta, 247, 00166, Rome, Italy. [20] Department of Radiation Hygiene and Radiobiology, National Institute of Public Health NIH - National Research Institute, 24 Chocimska Street, 00-791, Warsaw, Poland. [21] Laboratory for the Study of the Pathogenesis of Malignant Tumors, National Medical Research Center for Oncology, 14 line 63, 344037, Rostov-on-Don, Russia. [22] Institute of Biology, Medical Faculty, Slovak Medical University, Limbova 12, 83303, Bratislava, Slovakia. [23] Cancer Research Institute, Biomedical Research Center of the Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, Slovakia. [24] Grupo DICOMOSA, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Psicología, Facultad de Ciencias de La Educación, Universidade da Coruña, Campus Elviña s/n, 15071, A Coruña, Spain. [25] Instituto de Investigación Biomédica de A Coruña (INIBIC), AE CICA-INIBIC, Oza, 15071, A Coruña, Spain. [26] Grupo DICOMOSA, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Biología, Facultad de Ciencias, Universidade da Coruña, Campus A Zapateira s/n, 15071, A Coruña, Spain. [27] Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès (Barcelona), Spain. [28] Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Carlos III Institute of Health, 28029, Madrid, Spain. [29] Center of Biological Research, Faculty of Pharmacy, University of Belgrade, VojvodeStepe 450, Belgrade, Serbia. [30] Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France. [31] Univ Paris-Saclay, CESP, Villejuif, France. [32] ANTICIPE Unit, INSERM & University of Caen-Normandie Centre François Baclesse, Avenue du Général Harris, 14076, Caen Cedex 05, France. [33] Department of Biochemistry, Instituto de Ciencias Básicas Y Preclínicas "Victoria de Giron", Universidad de Ciencias Médicas de La Habana, 146 St. and 31 Ave, No, 3102, Playa, Habana, Cuba. [34] Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey. [35] Department of Non-Ionizing Radiation, National Public Health Center, Anna Street 5, 1221, Budapest, Hungary. [36] NILU, Health Effects Laboratory, Kjeller, Norway. [37] Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway. [38]
DOI 10.1038/s41598-021-95976-7
PMID 34408182
发布时间 2022-04-06
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