Osteoprotegerin (OPG) mediates the anti-carcinogenic effects of normal breast fibroblasts and targets cancer stem cells through inhibition of the β-catenin pathway.
第一作者:
Noura N,Alraouji
第一单位:
Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia.
作者:
主题词
抗体(Antibodies);抗致癌药(Anticarcinogenic Agents);乳腺肿瘤(Breast Neoplasms);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);上皮-间质转化(Epithelial-Mesenchymal Transition);女(雌)性(Female);成纤维细胞(Fibroblasts);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);白细胞介素6(Interleukin-6);NF-κB(NF-kappa B);肿瘤干细胞(Neoplastic Stem Cells);骨保护素(Osteoprotegerin);RANK配体(RANK Ligand);重组蛋白质类(Recombinant Proteins);STAT3转录因子(STAT3 Transcription Factor);β连环素(beta Catenin)
DOI
10.1016/j.canlet.2021.08.013
PMID
34416336
发布时间
2022-01-07
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Cancer letters
374-384页
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