PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum.
作者:
Karam T,Alhalabi [1]
;
Damian,Stichel [2]
;
Philipp,Sievers [3]
;
Heike,Peterziel [4]
;
Alexander C,Sommerkamp [5]
;
Dominik,Sturm [4]
;
Andrea,Wittmann [5]
;
Martin,Sill [1]
;
Natalie,Jäger [3]
;
Pengbo,Beck [1]
;
Kristian W,Pajtler [2]
;
Matija,Snuderl [1]
;
George,Jour [2]
;
Michael,Delorenzo [6]
;
Allison M,Martin [1]
;
Adam,Levy [2]
;
Nagma,Dalvi [7]
;
Jordan R,Hansford [1]
;
Nicholas G,Gottardo [7]
;
Emmanuelle,Uro-Coste [1]
;
Claude-Alain,Maurage [7]
;
Catherine,Godfraind [1]
;
Fanny,Vandenbos [7]
;
Torsten,Pietsch [6]
;
Christof,Kramm [8]
;
Maria,Filippidou [9]
;
Antonis,Kattamis [9]
;
Chris,Jones [10]
;
Ingrid,Øra [10]
;
Torben Stamm,Mikkelsen [11]
;
Michal,Zapotocky [12]
;
David,Sumerauer [13]
;
David,Scheie [14]
;
Martin,McCabe [15]
;
Pieter,Wesseling [16]
;
Bastiaan B J,Tops [17]
;
Mariëtte E G,Kranendonk [18]
;
Matthias A,Karajannis [19]
;
Nancy,Bouvier [20]
;
Elli,Papaemmanuil [21]
;
Hildegard,Dohmen [22]
;
Till,Acker [23]
;
Katja,von Hoff [1]
;
Simone,Schmid [7]
;
Evelina,Miele [24]
;
Katharina,Filipski [24]
;
Lidija,Kitanovski [25]
;
Lenka,Krskova [26]
;
Johannes,Gojo [27]
;
Christine,Haberler [28]
;
Frank,Alvaro [28]
;
Jonas,Ecker [29]
;
Florian,Selt [30]
;
Till,Milde [31]
;
Olaf,Witt [32]
;
Ina,Oehme [33]
;
Marcel,Kool [32]
;
Andreas,von Deimling [33]
;
Andrey,Korshunov [32]
;
Stefan M,Pfister [33]
;
Felix,Sahm [34]
;
David T W,Jones [35]
作者单位:
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
[1]
Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
[2]
Faculty of Medicine, Heidelberg University, Heidelberg, Germany.
[3]
Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.
[4]
Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[5]
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
[6]
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[7]
Division of Neuropathology, NYU Langone Health, New York, NY, USA.
[8]
Department of Pathology, NYU Langone Health, New York, NY, USA.
[9]
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.
[10]
Isabel Rapin Division of Child Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
[11]
Department of Pediatrics, Children's Cancer Centre, Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, VIC, Australia.
[12]
Department of Oncology and Haematology, Perth Children's Hospital, Perth, WA, Australia.
[13]
Department of Pathology, IUCT-Oncopole, Toulouse University Hospital, Toulouse, France.
[14]
INSERM U1037, Team 11, Cancer Research Center of Toulouse (CRCT), Toulouse, France.
[15]
Department of Pathology, Lille University Hospital, Lille, France.
[16]
INSERM U837 UMR-S1172, Centre de Recherche Jean Pierre Aubert, Team 1, Lille, France.
[17]
Laboratory of Pathology, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.
[18]
University Clermont-Auvergne, M2iSH UMR1071, Clermont-Ferrand, France.
[19]
Human Molecular Genetics, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
[20]
Department of Pathology, CHU Gabriel Montpied, Clermont-Ferrand, France.
[21]
Institute of Neuropathology, Brain Tumor Reference Center of the Society for Neuropathology and Neuroanatomy, University of Bonn Medical Center, Bonn, Germany.
[22]
Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Gottingen, Germany.
[23]
Division of Pediatric Hematology-Oncology, First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece.
[24]
Division of Molecular Pathology, Institute of Cancer Research, London, UK.
[25]
Children's Hospital, Paediatric Oncology, Skåne University Hospital, Lund, Sweden.
[26]
Paediatric and Adolescent Medicine, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
[27]
Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic.
[28]
Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
[29]
Division of Cancer Sciences, University of Manchester, Manchester, UK.
[30]
Department of Pathology, Brain Tumor Center Amsterdam University Medical Center, Amsterdam Universities Medical Centers/VUmc, Amsterdam, The Netherlands.
[31]
Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.
[32]
University Medical Center Utrecht, Utrecht, The Netherlands.
[33]
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, USA.
[34]
Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[35]
Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[36]
Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[37]
Department of Neuropathology, University Giessen, Giessen, Germany.
[38]
Department of Pediatric Oncology and Hematology, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
[39]
Department of Oncology, Hematology, Cell Therapy, Gene Therapy and Haemopoietic Transplant, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
[40]
Neurological Institute (Edinger Institute), University Hospital, Frankfurt, Germany.
[41]
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[42]
Frankfurt Cancer Institute (FCI), Frankfurt, Germany.
[43]
Division of Paediatrics, Department of Haematooncology, University Medical Center Ljubljana, Ljubljana, Slovenia.
[44]
Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
[45]
Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.
[46]
Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.
[47]
University of Newcastle, Newcastle, NSW, Australia.
[48]
John Hunter Children's Hospital Newcastle, Newcastle, NSW, Australia.
[49]
Clinical Cooperation Unit Pediatric Oncology, and German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[50]
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. david.jones@kitz-heidelberg.de.
[51]
Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. david.jones@kitz-heidelberg.de.
[52]
主题词
脑肿瘤(Brain Neoplasms);儿童(Child);儿童, 学龄前(Child, Preschool);女(雌)性(Female);人类(Humans);Kruppel样转录因子类(Kruppel-Like Transcription Factors);男(雄)性(Male);肿瘤, 神经上皮(Neoplasms, Neuroepithelial);癌基因融合(Oncogene Fusion);癌基因蛋白质类, 融合(Oncogene Proteins, Fusion);阻遏蛋白质类(Repressor Proteins)
DOI
10.1007/s00401-021-02354-8
PMID
34417833
发布时间
2024-02-10
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Acta neuropathologica
Acta neuropathologica
841-857页
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