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PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum.

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作者单位: Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. [1] Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. [2] Faculty of Medicine, Heidelberg University, Heidelberg, Germany. [3] Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany. [4] Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [5] Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany. [6] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [7] Division of Neuropathology, NYU Langone Health, New York, NY, USA. [8] Department of Pathology, NYU Langone Health, New York, NY, USA. [9] Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA. [10] Isabel Rapin Division of Child Neurology, Albert Einstein College of Medicine, Bronx, New York, USA. [11] Department of Pediatrics, Children's Cancer Centre, Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, VIC, Australia. [12] Department of Oncology and Haematology, Perth Children's Hospital, Perth, WA, Australia. [13] Department of Pathology, IUCT-Oncopole, Toulouse University Hospital, Toulouse, France. [14] INSERM U1037, Team 11, Cancer Research Center of Toulouse (CRCT), Toulouse, France. [15] Department of Pathology, Lille University Hospital, Lille, France. [16] INSERM U837 UMR-S1172, Centre de Recherche Jean Pierre Aubert, Team 1, Lille, France. [17] Laboratory of Pathology, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France. [18] University Clermont-Auvergne, M2iSH UMR1071, Clermont-Ferrand, France. [19] Human Molecular Genetics, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium. [20] Department of Pathology, CHU Gabriel Montpied, Clermont-Ferrand, France. [21] Institute of Neuropathology, Brain Tumor Reference Center of the Society for Neuropathology and Neuroanatomy, University of Bonn Medical Center, Bonn, Germany. [22] Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Gottingen, Germany. [23] Division of Pediatric Hematology-Oncology, First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece. [24] Division of Molecular Pathology, Institute of Cancer Research, London, UK. [25] Children's Hospital, Paediatric Oncology, Skåne University Hospital, Lund, Sweden. [26] Paediatric and Adolescent Medicine, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. [27] Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic. [28] Department of Clinical Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. [29] Division of Cancer Sciences, University of Manchester, Manchester, UK. [30] Department of Pathology, Brain Tumor Center Amsterdam University Medical Center, Amsterdam Universities Medical Centers/VUmc, Amsterdam, The Netherlands. [31] Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands. [32] University Medical Center Utrecht, Utrecht, The Netherlands. [33] Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, USA. [34] Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [35] Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [36] Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [37] Department of Neuropathology, University Giessen, Giessen, Germany. [38] Department of Pediatric Oncology and Hematology, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Berlin, Germany. [39] Department of Oncology, Hematology, Cell Therapy, Gene Therapy and Haemopoietic Transplant, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. [40] Neurological Institute (Edinger Institute), University Hospital, Frankfurt, Germany. [41] German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [42] Frankfurt Cancer Institute (FCI), Frankfurt, Germany. [43] Division of Paediatrics, Department of Haematooncology, University Medical Center Ljubljana, Ljubljana, Slovenia. [44] Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University, Prague, Czech Republic. [45] Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria. [46] Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria. [47] University of Newcastle, Newcastle, NSW, Australia. [48] John Hunter Children's Hospital Newcastle, Newcastle, NSW, Australia. [49] Clinical Cooperation Unit Pediatric Oncology, and German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [50] Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. david.jones@kitz-heidelberg.de. [51] Division of Pediatric Glioma Research (B360), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. david.jones@kitz-heidelberg.de. [52]
DOI 10.1007/s00401-021-02354-8
PMID 34417833
发布时间 2024-02-10
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