Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19?

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作者： Mariele,Montanari ^[1] ; Barbara,Canonico ^[1] ; Evelyn,Nordi ^[1] ; Daniela,Vandini ^[2] ; Simone,Barocci ^[2] ; Serena,Benedetti ^[1] ; Eugenio,Carlotti ^[3] ; Loris,Zamai ^[4]

作者单位： Department of Biomolecular Sciences, University of Urbino "Carlo Bo", 61029, Urbino, Italy. ^[1] Department of Clinical Pathology, ASUR Marche AV1, Urbino, PU, Italy. ^[2] Department of Prevention, ASUR Marche AV1, Urbino, PU, Italy. ^[3] Department of Biomolecular Sciences, University of Urbino "Carlo Bo", 61029, Urbino, Italy; INFN-Gran Sasso National Laboratory, Assergi, 67100, L', Aquila, Italy. Electronic address: loris.zamai@uniurb.it. ^[4]

关键词 ADAM17 RAS inhibitors Renin-angiotensin system Spike N-Terminal domain Zinc-chelating agents Zinc-metalloproteases

主题词血管紧张素Ⅰ(Angiotensin I);基因表达调控, 酶学(Gene Expression Regulation, Enzymologic);人类(Humans);肽碎片(Peptide Fragments);肾素-血管紧张素系统(Renin-Angiotensin System);增量调节(Up-Regulation)

DOI 10.1016/j.jbior.2021.100820

PMID 34419773

发布时间 2023-06-05

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