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Phase 2 Trial of Oncolytic H-1 Parvovirus Therapy Shows Safety and Signs of Immune System Activation in Patients With Metastatic Pancreatic Ductal Adenocarcinoma.

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作者单位: Coordination Centre for Clinical Trials, University Hospital, Marsilius-Arkaden, Tower West, Heidelberg, Germany. jacek.hajda@med.uni-heidelberg.de guy.ungerechts@nct-heidelberg.de. [1] Virus Production & Development Unit (VP&DU), Division of Tumor Virology (F010), German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] Clinical Cooperation Unit Virotherapy (F230), German Cancer Research Center (DKFZ), Heidelberg, Germany. [3] University Hospital Pharmacy, Heidelberg, Germany. [4] Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Marsilius-Arkaden, Tower West, Heidelberg, Germany. [5] Oryx GmbH & Co. KG, Baldham, Germany. [6] Department of Medical Oncology, University Hospital Heidelberg and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany. [7] Faculty of Health/School of Medicine, Institute of Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Germany. [8] Tissue Imaging & Analysis Center (TIGA), BioQuant, University Heidelberg, Heidelberg, Germany. [9] Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [10] Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany. [11] Institute of Pathology, University Medical Center, University Mainz, Mainz, Germany. [12] Department of Transplantation-Immunology, Institute of Immunology, University Heidelberg, Heidelberg, Germany. [13] Clinical Cooperation Unit Virotherapy (F230), German Cancer Research Center (DKFZ), Heidelberg, Germany. jacek.hajda@med.uni-heidelberg.de guy.ungerechts@nct-heidelberg.de. [14]
DOI 10.1158/1078-0432.CCR-21-1020
PMID 34426438
发布时间 2022-04-01
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Clinical cancer research : an official journal of the American Association for Cancer Research

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