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A Combination of Metagenomic and Cultivation Approaches Reveals Hypermutator Phenotypes within Vibrio cholerae-Infected Patients.

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第一作者： Inès,Levade

第一单位： Department of Biological Sciences, University of Montreal, Montreal, Quebec, Canada.;Department of Microbiology and Immunology, McGill Universitygrid.14709.3b, Montreal, Quebec, Canada.

作者： Inès,Levade ^[1] ; Ashraful I,Khan ^[2] ; Fahima,Chowdhury ^[2] ; Stephen B,Calderwood ^[3] ; Edward T,Ryan ^[4] ; Jason B,Harris ^[5] ; Regina C,LaRocque ^[4] ; Taufiqur R,Bhuiyan ^[2] ; Firdausi,Qadri ^[2] ; Ana A,Weil ^[6] ; B Jesse,Shapiro ^[7]

作者单位： Department of Biological Sciences, University of Montreal, Montreal, Quebec, Canada.;Department of Microbiology and Immunology, McGill Universitygrid.14709.3b, Montreal, Quebec, Canada. ^[1] Center for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. ^[2] Division of Infectious Diseases, Massachusetts General Hospitalgrid.32224.35, Boston, Massachusetts, USA.;Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.;Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA. ^[3] Division of Infectious Diseases, Massachusetts General Hospitalgrid.32224.35, Boston, Massachusetts, USA.;Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. ^[4] Division of Infectious Diseases, Massachusetts General Hospitalgrid.32224.35, Boston, Massachusetts, USA.;Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. ^[5] Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA. ^[6] Department of Biological Sciences, University of Montreal, Montreal, Quebec, Canada.;Department of Microbiology and Immunology, McGill Universitygrid.14709.3b, Montreal, Quebec, Canada.;McGill Genome Centre, Montreal, Quebec, Canada. ^[7]

关键词 Vibrio cholerae asymptomatic carriage cholera convergent evolution genomics hypermutation intrahost diversity metagenomics natural selection population genetics within-patient evolution

DOI 10.1128/mSystems.00889-21

PMID 34427503

发布时间 2021-12-15

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