换一批
换一批An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates.
作者：
Nerea,Zabaleta [1]
;
Wenlong,Dai [1]
;
Urja,Bhatt [1]
;
Cécile,Hérate [2]
;
Pauline,Maisonnasse [2]
;
Jessica A,Chichester [3]
;
Julio,Sanmiguel [1]
;
Reynette,Estelien [1]
;
Kristofer T,Michalson [3]
;
Cheikh,Diop [1]
;
Dawid,Maciorowski [1]
;
Nathalie,Dereuddre-Bosquet [2]
;
Mariangela,Cavarelli [2]
;
Anne-Sophie,Gallouët [2]
;
Thibaut,Naninck [2]
;
Nidhal,Kahlaoui [2]
;
Julien,Lemaitre [2]
;
Wenbin,Qi [4]
;
Elissa,Hudspeth [5]
;
Allison,Cucalon [1]
;
Cecilia D,Dyer [3]
;
M Betina,Pampena [6]
;
James J,Knox [7]
;
Regina C,LaRocque [8]
;
Richelle C,Charles [8]
;
Dan,Li [1]
;
Maya,Kim [1]
;
Abigail,Sheridan [1]
;
Nadia,Storm [9]
;
Rebecca I,Johnson [9]
;
Jared,Feldman [10]
;
Blake M,Hauser [10]
;
Vanessa,Contreras [2]
;
Romain,Marlin [2]
;
Raphaël Ho,Tsong Fang [2]
;
Catherine,Chapon [2]
;
Sylvie,van der Werf [11]
;
Eric,Zinn [1]
;
Aisling,Ryan [1]
;
Dione T,Kobayashi [12]
;
Ruchi,Chauhan [1]
;
Marion,McGlynn [3]
;
Edward T,Ryan [13]
;
Aaron G,Schmidt [14]
;
Brian,Price [15]
;
Anna,Honko [9]
;
Anthony,Griffiths [9]
;
Sam,Yaghmour [4]
;
Robert,Hodge [16]
;
Michael R,Betts [6]
;
Mason W,Freeman [17]
;
James M,Wilson [3]
;
Roger,Le Grand [18]
;
Luk H,Vandenberghe [19]
作者单位：
Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, MA, USA; Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; The Broad Institute of Harvard and MIT, Cambridge, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
[1]
Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France.
[2]
Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[3]
Novartis Gene Therapies, San Diego, CA, USA.
[4]
Novartis Gene Therapies, NC, USA.
[5]
Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[6]
Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[7]
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
[8]
Department of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA 02118, USA.
[9]
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
[10]
Molecular Genetics of RNA Viruses, Department of Virology, Institut Pasteur, CNRS UMR 3569, Université de Paris, Paris, France; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France.
[11]
Translational Innovation Fund, Mass General Brigham Innovation, Cambridge, MA, USA.
[12]
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
[13]
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Microbiology, Harvard Medical School, Boston, MA, USA.
[14]
Albamunity, Boston, MA, USA.
[15]
Novartis Gene Therapies, Libertyville, IL, USA.
[16]
Center for Computational & Integrative Biology, Department of Medicine, and Translational Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
[17]
Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, Fontenay-aux-Roses, France. Electronic address: roger.le-grand@cea.fr.
[18]
Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, MA, USA; Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; The Broad Institute of Harvard and MIT, Cambridge, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Electronic address: luk_vandenberghe@meei.harvard.edu.
[19]
主题词
动物(Animals);抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);依赖病毒(Dependovirus);女(雌)性(Female);人类(Humans);免疫记忆(Immunologic Memory);成束猴(Macaca fascicularis);猕猴(Macaca mulatta);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);T淋巴细胞(T-Lymphocytes);转基因(Transgenes);接种(Vaccination);病毒载量(Viral Load)
DOI
10.1016/j.chom.2021.08.002
PMID
34428428
发布时间
2024-09-23
- 浏览7
Cell host & microbe
Cell host & microbe
1437-1453.e8页
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