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首页> The Journal of biological chemistry> S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity.

S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity.

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作者： Robbins,Puthenveetil ^[1] ; Cheng Man,Lun ^[2] ; R Elliot,Murphy ^[1] ; Liam B,Healy ^[1] ; Geraldine,Vilmen ^[2] ; Eric T,Christenson ^[1] ; Eric O,Freed ^[2] ; Anirban,Banerjee ^[3]

作者单位： Section on Structural and Chemical Biology of Membrane Proteins, Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. ^[1] Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA. ^[2] Section on Structural and Chemical Biology of Membrane Proteins, Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: anirban.banerjee@nih.gov. ^[3]

关键词 SARS-CoV-2 in vitro reconstitution infectious disease membrane enzyme membrane protein posttranslational modification (PTM)protein palmitoylation spike protein viral protein zDHHC enzyme

主题词酰化作用(Acylation);酰基转移酶类(Acyltransferases);氨基酸序列(Amino Acid Sequence);半胱氨酸(Cysteine);HEK293细胞(HEK293 Cells);人类(Humans);脂化作用(Lipoylation);诱变, 定点(Mutagenesis, Site-Directed);重组蛋白质类(Recombinant Proteins);序列比对(Sequence Alignment);病毒内化(Virus Internalization)

DOI 10.1016/j.jbc.2021.101112

PMID 34428449

发布时间 2021-11-10

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The Journal of biological chemistry

The Journal of biological chemistry

2021年297卷4期

101112页

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