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首页> Immunology> Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8<sup>+</sup> T cell immunosenescence signature linked to immunopathology.

Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8<sup>+</sup> T cell immunosenescence signature linked to immunopathology.

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作者： Carlos Henrique,Fantecelle ^[1] ; Luciana Polaco,Covre ^[1] ; Renan,Garcia de Moura ^[2] ; Herbert Leonel de Matos,Guedes ^[1] ; Camila Farias,Amorim ^[3] ; Phillip,Scott ^[4] ; David,Mosser ^[5] ; Aloisio,Falqueto ^[5] ; Arne N,Akbar ^[6] ; Daniel Claudio Oliveira,Gomes ^[7]

作者单位： Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, Brazil. ^[1] Division of Medicine, University College London, London, UK. ^[2] Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. ^[3] Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil. ^[4] Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[5] Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA. ^[6] Departamento de Medicina Social, Universidade Federal do Espírito Santo, Vitoria, Brazil. ^[7] Núcleo de Biotecnologia, Universidade Federal do Espírito Santo, Vitoria, Brazil. ^[8]

关键词 Leishmania braziliensis cutaneous leishmaniasis immunopathogenesis immunosenescence senescence-associated secretory phenotype

主题词活组织检查(Biopsy);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);计算生物学(Computational Biology);细胞因子类(Cytokines);数据库, 遗传学(Databases, Genetic);疾病易感性(Disease Susceptibility);基因表达谱(Gene Expression Profiling);基因表达调控(Gene Expression Regulation);人类(Humans);炎症介导素类(Inflammation Mediators);巴西利什曼原虫(Leishmania braziliensis);利什曼病, 皮肤(Leishmaniasis, Cutaneous);皮肤(Skin)

DOI 10.1111/imm.13410

PMID 34432883

发布时间 2022-12-02

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Immunology

Immunology

2021年164卷4期

754-765页

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2021年164卷4期

754-765页

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