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Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease.

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第一作者： Tânia,Fernandes

第一单位： CNC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.;IIIUC-Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal.;CACC-Clinical Academic Center of Coimbra, 3004-561 Coimbra, Portugal.;Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

作者： Tânia,Fernandes ^[1] ; Rosa,Resende ^[2] ; Diana F,Silva ^[2] ; Ana P,Marques ^[2] ; Armanda E,Santos ^[3] ; Sandra M,Cardoso ^[4] ; M Rosário,Domingues ^[5] ; Paula I,Moreira ^[4] ; Cláudia F,Pereira ^[4]

作者单位： CNC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.;IIIUC-Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal.;CACC-Clinical Academic Center of Coimbra, 3004-561 Coimbra, Portugal.;Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. ^[1] CNC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.;IIIUC-Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal.;CACC-Clinical Academic Center of Coimbra, 3004-561 Coimbra, Portugal. ^[2] CNC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.;Laboratory of Biochemistry and Biology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. ^[3] CNC-Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.;CACC-Clinical Academic Center of Coimbra, 3004-561 Coimbra, Portugal.;Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. ^[4] Mass Spectrometry Centre, REQUIMTE-LAQV and CESAM, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. ^[5]

关键词 Alzheimer’s disease Ca2+ signaling ER-mitochondria contacts mitochondrial dysfunction subcellular fractions

DOI 10.3390/biomedicines9080881

PMID 34440085

发布时间 2021-08-30

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2021年9卷8期

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2021年9卷8期

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Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease.

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Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease.

Biomedicines

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Biomedicines

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