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首页> Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie> JNK downregulation improves olanzapine-induced insulin resistance by suppressing IRS1<sup>Ser307</sup> phosphorylation and reducing inflammation.

JNK downregulation improves olanzapine-induced insulin resistance by suppressing IRS1<sup>Ser307</sup> phosphorylation and reducing inflammation.

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作者： Huqun,Li ^[1] ; Chongshu,Wang ^[2] ; Jiefang,Zhao ^[2] ; Cuilian,Guo ^[3]

作者单位： Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China. ^[1] Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ^[2] Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: guocuilian2019@hotmail.com. ^[3]

关键词 Adipose tissue IRS1 Insulin resistance JNK1 Olanzapine

主题词 3T3-L1细胞(3T3-L1 Cells);脂细胞(Adipocytes);脂肪组织(Adipose Tissue);动物(Animals);抗精神病药(Antipsychotic Agents);减量调节(Down-Regulation);女(雌)性(Female);基因敲低技术(Gene Knockdown Techniques);葡萄糖(Glucose);炎症(Inflammation);胰岛素(Insulin);胰岛素受体底物蛋白质类(Insulin Receptor Substrate Proteins);胰岛素抗药性(Insulin Resistance);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);丝裂原活化蛋白激酶8(Mitogen-Activated Protein Kinase 8);磷酰化(Phosphorylation)

DOI 10.1016/j.biopha.2021.112071

PMID 34449309

发布时间 2022-01-06

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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