Metformin Prevents Hyperglycemia-Associated, Oxidative Stress-Induced Vascular Endothelial Dysfunction: Essential Role for the Orphan Nuclear Receptor Human Nuclear Receptor 4A1 (Nur77).

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作者： Vivek Krishna Pulakazhi,Venu ^[1] ; Mahmoud,Saifeddine ^[2] ; Koichiro,Mihara ^[2] ; Muniba,Faiza ^[2] ; Evgueni,Gorobets ^[2] ; Andrew J,Flewelling ^[2] ; Darren J,Derksen ^[2] ; Simon A,Hirota ^[2] ; Isra,Marei ^[2] ; Dana,Al-Majid ^[2] ; Majid,Motahhary ^[2] ; Hong,Ding ^[2] ; Chris R,Triggle ^[2] ; Morley D,Hollenberg ^[1]

作者单位： Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India mhollenb@ucalgary.ca vivek.pulakazhivenu@ucalgary.ca. ^[1] Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India. ^[2]