Cardioprotective effects of melatonin and metformin against doxorubicin-induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics.

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作者： Apiwan,Arinno ^[1] ; Chayodom,Maneechote ^[2] ; Thawatchai,Khuanjing ^[1] ; Benjamin,Ongnok ^[1] ; Nanthip,Prathumsap ^[1] ; Titikorn,Chunchai ^[2] ; Busarin,Arunsak ^[2] ; Sasiwan,Kerdphoo ^[2] ; Krekwit,Shinlapawittayatorn ^[1] ; Siriporn C,Chattipakorn ^[2] ; Nipon,Chattipakorn ^[3]

作者单位： Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai 50200, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. ^[1] Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai 50200, Thailand. ^[2] Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai 50200, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address: nchattip@gmail.com. ^[3]

关键词 Doxorubicin-induced cardiotoxicity Heart Melatonin Metformin Mitochondria