Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.

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作者： Hongyan,Wang ^[1] ; Jie,Ai ^[1] ; Abdullah,Shopit ^[1] ; Mengyue,Niu ^[1] ; Nisar,Ahmed ^[1] ; Tsehaye,Tesfaldet ^[1] ; Zhongyuan,Tang ^[2] ; Xiaodong,Li ^[3] ; Yazeed,Jamalat ^[1] ; Peng,Chu ^[1] ; Jinyong,Peng ^[1] ; Xiaodong,Ma ^[1] ; Eskandar,Qaed ^[1] ; Guozhu,Han ^[1] ; Weisheng,Zhang ^[4] ; Jun,Wang ^[5] ; Zeyao,Tang ^[6]

作者单位： Acad Integrated Med & College of Pharmacy, Department of Pharmacology, Dalian Medical University, 9 Western Section, Lvshun South Street, Dalian, 116044, China. ^[1] Department of Jilin University, Changchun, China. ^[2] Second Clinical College, Dalian Medical University, Dalian, China. ^[3] First Clinical College, Dalian Medical University, 9 Western Section, Lvshun South Street, Dalian, 116044, China. 11111210027@fudan.edu.cn. ^[4] Department of Pathophysiology, Dalian Medical University, 9 Western Section, Lvshun South Street, Dalian, 116044, China. Junwangw@yahoo.com. ^[5] Acad Integrated Med & College of Pharmacy, Department of Pharmacology, Dalian Medical University, 9 Western Section, Lvshun South Street, Dalian, 116044, China. zeyaotang@163.com. ^[6]

关键词 Cyclophilin D Methylglyoxal Mitochondria Pancreatic β-cells Phosphocreatine