Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.

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作者： Camila,Prieto ^[1] ; Diu T T,Nguyen ^[1] ; Zhaoqi,Liu ^[2] ; Justin,Wheat ^[3] ; Alexendar,Perez ^[4] ; Saroj,Gourkanti ^[5] ; Timothy,Chou ^[1] ; Ersilia,Barin ^[1] ; Anthony,Velleca ^[1] ; Thomas,Rohwetter ^[1] ; Arthur,Chow ^[1] ; James,Taggart ^[1] ; Angela M,Savino ^[1] ; Katerina,Hoskova ^[1] ; Meera,Dhodapkar ^[1] ; Alexandra,Schurer ^[1] ; Trevor S,Barlowe ^[1] ; Ly P,Vu ^[1] ; Christina,Leslie ^[6] ; Ulrich,Steidl ^[5] ; Raul,Rabadan ^[4] ; Michael G,Kharas ^[2]

作者单位： Molecular Pharmacology Program and Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[1] Program for Mathematical Genomics, Department of Systems Biology, Department of Biomedical Informatics, Columbia University Medical Center, New York, NY, USA. ^[2] CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing 100101, China. ^[3] Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY USA. ^[4] Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[5] Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, BC, Canada; Molecular Biology and Biochemistry, Simon Fraser University, Vancouver, BC, Canada. ^[6]

主题词动物(Animals);染色质(Chromatin);基因表达调控(Gene Expression Regulation);核不均一核糖核蛋白类(Heterogeneous-Nuclear Ribonucleoproteins);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);小鼠(Mice);RNA结合蛋白质类(RNA-Binding Proteins);转录因子(Transcription Factors)

DOI 10.1038/s43018-021-00220-w

PMID 34458856

发布时间 2024-06-07

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Nature cancer

2021年2卷

741-757页

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Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.

Nature cancer

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Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.

Nature cancer

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Nature cancer

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