Efficacy and safety of dupilumab in patients with uncontrolled severe chronic rhinosinusitis with nasal polyps and a clinical diagnosis of NSAID-ERD: Results from two randomized placebo-controlled phase 3 trials.

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作者： Joaquim,Mullol ^[1] ; Tanya M,Laidlaw ^[2] ; Claus,Bachert ^[3] ; Leda P,Mannent ^[4] ; G Walter,Canonica ^[5] ; Joseph K,Han ^[6] ; Jorge F,Maspero ^[7] ; Cesar,Picado ^[8] ; Nadia,Daizadeh ^[9] ; Benjamin,Ortiz ^[10] ; Yongtao,Li ^[11] ; Marcella,Ruddy ^[12] ; Elizabeth,Laws ^[13] ; Nikhil,Amin ^[14]

作者单位： Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, IDIBAPS, Universitat de Barcelona, CIBERES, Barcelona, Catalonia, Spain. ^[1] Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA. ^[2] Upper Airways Research Laboratory and Department of Otorhinolaryngology, Ghent University, Ghent, Belgium. ^[3] Division of ENT Diseases, CLINTEX, Karolinska Institutet, Stockholm, Sweden. ^[4] First Affiliated Hosptial, Sun Yat-sen University, Guangzhou, China. ^[5] Global Clinical Development, Sanofi, Chilly-Mazarin, France. ^[6] Department of Biomedical Sciences, Humanitas University, Personalized Medicine Asthma & Allergy Unit-IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. ^[7] Department of Otolaryngology & Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia, USA. ^[8] Allergy and Respiratory Medicine, Fundación CIDEA, Buenos Aires, Argentina. ^[9] Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, Universitat de Barcelona, CIBERES, Barcelona, Catalonia, Spain. ^[10] Biostatistics, Sanofi, Cambridge, Massachusetts, USA. ^[11] Immunology and Allergy Medical Affairs, Regeneron Pharmaceuticals, Inc., New York, USA. ^[12] Global Medical Affairs Respiratory, Sanofi, Bridgewater, New Jersey, USA. ^[13] Clinical Sciences Global Development, Regeneron Pharmaceuticals, Inc., Tarrytown, New Jersey, USA. ^[14] Immunology and Inflammation, Sanofi, Bridgewater, New Jersey, USA. ^[15]

关键词 IL-13 IL-4 chronic rhinosinusitis with nasal polyps dupilumab non-steroidal anti-inflammatory drug-exacerbated respiratory disease