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Determining a healthy reference range and factors potentially influencing PRO-C3 - A biomarker of liver fibrosis.

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第一作者： Elisabeth,Erhardtsen

第一单位： Nordic Bioscience Biomarkers and Research, Herlev, Denmark.

作者： Elisabeth,Erhardtsen ^[1] ; Daniel G K,Rasmussen ^[1] ; Peder,Frederiksen ^[1] ; Diana Julie,Leeming ^[1] ; Diane,Shevell ^[2] ; Lise Lotte,Gluud ^[3] ; Morten Asser,Karsdal ^[1] ; Guruprasad P,Aithal ^[4] ; Jörn M,Schattenberg ^[5]

作者单位： Nordic Bioscience Biomarkers and Research, Herlev, Denmark. ^[1] Innovative Medicine, Bristol Myers-Squibb, Princeton, NJ, USA. ^[2] Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;Gastro Unit, Medical Division, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark. ^[3] Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.;NIHR Nottingham Biomedical Research Centre at the Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.;Medical Research Council (MRC), Nottingham Molecular Pathology Node, University of Nottingham, Nottingham, UK. ^[4] Department of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany. ^[5]

关键词 ADAM, A Disintegrin and Metalloproteases ALP, alkaline phosphatase ALT, alanine aminotransferase AST, aspartate aminotransferase AUROC, area under the receiver operating characteristics curve Biomarkers Biopsy Body mass index CLSI, Clinical and Laboratory Standards Institute Collagen type III ELF? test, Enhanced Liver Fibrosis test Ethnic groups FIB-4, fibrosis-4 Fibrosis Healthy volunteers Hospitals Humans LITMUS, Liver Investigation: Testing Marker Utility in Steatohepatitis (consortium)NAFLD, non-alcoholic fatty liver disease NAS, NAFLD Activity Score NASH, non-alcoholic steatohepatitis NASH-CRN, NASH Clinical Research Network NIMBLE, Non-Invasive Biomarkers of Metabolic Liver Disease (consortium)NPV, negative predictive value Non-alcoholic fatty liver disease PPV, positive predictive value Reference standards Reference values T2DM, type 2 diabetes mellitus

DOI 10.1016/j.jhepr.2021.100317

PMID 34466796

发布时间 2024-04-03

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Determining a healthy reference range and factors potentially influencing PRO-C3 - A biomarker of liver fibrosis.

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Determining a healthy reference range and factors potentially influencing PRO-C3 - A biomarker of liver fibrosis.

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