Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.

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作者： Thomas R,Müller ^[1] ; Sebastian,Jarosch ^[2] ; Monika,Hammel ^[1] ; Justin,Leube ^[1] ; Simon,Grassmann ^[1] ; Bettina,Bernard ^[1] ; Manuel,Effenberger ^[3] ; Immanuel,Andrä ^[1] ; M Zeeshan,Chaudhry ^[1] ; Theresa,Käuferle ^[1] ; Antje,Malo ^[4] ; Luka,Cicin-Sain ^[5] ; Peter,Steinberger ^[2] ; Tobias,Feuchtinger ^[6] ; Ulrike,Protzer ^[7] ; Kathrin,Schumann ^[4] ; Michael,Neuenhahn ^[5] ; Kilian,Schober ^[8] ; Dirk H,Busch ^[2]

作者单位： Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany. ^[1] German Center for Infection Research (DZIF), partner site Munich, Munich, Germany. ^[2] Immunology Program, Memorial Sloan Kettering Cancer Center, New York, USA. ^[3] Department of Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany. ^[4] German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Braunschweig, Germany. ^[5] Department of Pediatric Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany. ^[6] Institute of Virology, TUM, Munich, Germany. ^[7] Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. ^[8] Institute for Advanced Study, TUM, Munich, Germany. ^[9]

关键词 CRISPR/Cas9 mediated engineering OTR T cell receptor engineering TCR TCR editing TCR transgenic T cells homogenous TCR expreession orthotopic TCR replacement predictable functionality

主题词动物(Animals);细胞系(Cell Line);细胞膜(Cell Membrane);女(雌)性(Female);基因, T细胞受体(Genes, T-Cell Receptor);人类(Humans);免疫疗法(Immunotherapy);男(雄)性(Male);小鼠, 近交NOD(Mice, Inbred NOD);T淋巴细胞(T-Lymphocytes);转录, 遗传(Transcription, Genetic);小鼠(Mice)

DOI 10.1016/j.xcrm.2021.100374

PMID 34467251

发布时间 2024-02-26

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Cell reports. Medicine

2021年2卷8期

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Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.

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Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.

Cell reports. Medicine

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