Effects of Manufacturing Process Variables on the Tablet Weight Variation of Mini-tablets Clarified by a Definitive Screening Design.

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第一作者： Shui,Usuda

第一单位： Laboratory of Pharmaceutical Technology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama.

作者： Shui,Usuda ^[1] ; Naohiro,Masukawa ^[2] ; Kok Hoong,Leong ^[3] ; Kotaro,Okada ^[1] ; Yoshinori,Onuki ^[1]

作者单位： Laboratory of Pharmaceutical Technology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama. ^[1] JMP Japan, SAS Institute Japan Ltd. ^[2] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Malaya. ^[3]

关键词 definitive screening design fluidized bed granulator granule property mini-tablet tablet weight variation wet granulation

主题词药物设计(Drug Design);药物评价, 临床前(Drug Evaluation, Preclinical);分子量(Molecular Weight);粒子大小(Particle Size);片剂(Tablets)

DOI 10.1248/cpb.c21-00427

PMID 34470954

发布时间 2021-10-12

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准确一般字义偏差语意偏离译文作用小提交