换一批Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase - Design, synthesis and biological evaluation.
第一作者：
Chandran,Remya
第一单位：
Department of Biotechnology and Microbiology, Kannur University, Dr. Janaki Ammal Campus, Thalassery, Kerala 670661, India.
作者：
关键词
AChE, acetylcholinesteraseAChEIs, acetylcholinesterase inhibitorsAChT, acetylthiocholineAD, Alzheimer’s diseaseADME, absorption, distribution, metabolism and excretionAcetylcholinesteraseAlzheimer’s diseaseBBB, blood brain barrierCa2+, calciumChE, CholinesterasesDMEM, Dulbecco’s modified Eagle’s mediumDTNB, 5,5-dithiobis-(2-nitrobenzoic acid)ENM, elastic network modelingER, endoplasmic reticulumFRET, fluorescence resonance energy transferG6PD, glucose-6-phosphate dehydrogenaseHBSS, Hank's balanced salt solutionIP, intraperitonealLBD, Ligand binding domainLC-MS, Liquid chromatography-mass spectrometryLiCABEDS, Ligand Classifier of Adaptively Boosting Ensemble Decision StumpsMAP2, microtubule associated protein 2MD, Molecular dynamicsMTDLsMTDLs, multi-target directed ligandsMWM, Morris water mazeNBM, neurobasal mediumNMA, normal mode analysisNMDA receptorNMDAR, N-methyl-D-aspartate receptorNeuroprotectionOPLS, Optimized potential for liquid simulationsPBS, phosphate-buffered salinePFA, paraformaldehydePolypharmacologyRMSD, root mean square deviationSAR, structure-activity relationshipsSD, standard deviationSVM, support vector machineStructure-based drug designTBI, traumatic brain injuryTMD, transmembrane domainTacrineh-NMDAR, human NMDARhAChE, human AChEppm, parts per million
DOI
10.1016/j.csbj.2021.07.041
PMID
34471497
发布时间
2021-09-03
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