LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5.

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第一作者： Yan,Zheng

第一单位： Research Center of Translational Medicine, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

作者： Yan,Zheng ^[1] ; Tianshui,Lei ^[2] ; Guangfu,Jin ^[3] ; Haiyang,Guo ^[2] ; Nasha,Zhang ^[4] ; Jie,Chai ^[5] ; Mengyu,Xie ^[6] ; Yeyang,Xu ^[7] ; Tianpei,Wang ^[2] ; Jiandong,Liu ^[2] ; Yue,Shen ^[4] ; Yemei,Song ^[2] ; Bowen,Wang ^[2] ; Jinming,Yu ^[2] ; Ming,Yang ^[2]

作者单位： Research Center of Translational Medicine, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, China. ^[1] Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. ^[2] Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. ^[3] Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. ^[4] Clinical Laboratory, Tumor Marker Detection Engineering Laboratory of Shandong Province, The Second Hospital of Shandong University, Jinan, China. ^[5] Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. ^[6] Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. ^[7]

关键词 DDX5 Pol II gastric cancer lncPSCA risk variant

主题词 DEAD-box RNA解旋酶类(DEAD-box RNA Helicases);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);全基因组关联研究(Genome-Wide Association Study);人类(Humans);胃肿瘤(Stomach Neoplasms);转录因子(Transcription Factors)

DOI 10.15252/embr.202152707

PMID 34472665

发布时间 2022-11-05

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