Multifunctional silica-coated mixed polymeric micelles for integrin-targeted therapy of pediatric patient-derived glioblastoma.

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作者： Prakram Singh,Chauhan ^[1] ; Murali,Kumarasamy ^[2] ; Angel M,Carcaboso ^[3] ; Alejandro,Sosnik ^[4] ; Dganit,Danino ^[5]

作者单位： CryoEM Laboratory of Soft Matter, Faculty of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa 3200003, Israel. ^[1] Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel. ^[2] Institut de Recerca Sant Joan de Deu, Department of Pediatric Oncology, Hospital Sant Joan de Deu, 08950 Barcelona, Spain. Electronic address: amontero@fsjd.org. ^[3] Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel. Electronic address: sosnik@technion.ac.il. ^[4] CryoEM Laboratory of Soft Matter, Faculty of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa 3200003, Israel; Biotechnology and Food Engineering, Guangdong Technion-Israel Institute of Technology, Shantou 515063, China. Electronic address: danino@bfe.technion.ac.il. ^[5]

关键词 Blood-brain barrier Glioblastoma Mixed polymeric micelles Pediatric cancer Pluronic? F127 and Tetronic? 1307 Silica shell αvβ3 integrin receptor