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Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells.

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第一作者： Paul D,Donohoue

第一单位： Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: donohoue@cariboubio.com.

作者： Paul D,Donohoue ^[1] ; Martin,Pacesa ^[2] ; Elaine,Lau ^[3] ; Bastien,Vidal ^[3] ; Matthew J,Irby ^[3] ; David B,Nyer ^[3] ; Tomer,Rotstein ^[3] ; Lynda,Banh ^[3] ; Mckenzi S,Toh ^[3] ; Jason,Gibson ^[3] ; Bryan,Kohrs ^[3] ; Kevin,Baek ^[3] ; Arthur L G,Owen ^[3] ; Euan M,Slorach ^[3] ; Megan,van Overbeek ^[3] ; Christopher K,Fuller ^[3] ; Andrew P,May ^[4] ; Martin,Jinek ^[5] ; Peter,Cameron ^[6]

作者单位： Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: donohoue@cariboubio.com. ^[1] Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. ^[2] Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. ^[3] Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: apmay1@gmail.com. ^[4] Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: jinek@bioc.uzh.ch. ^[5] Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: pscameron@gmail.com. ^[6]

关键词 CRISPR-Cas CRISRP hybrid RNA-DNA Cas9 chRDNA off-target editing