Fast and efficient correction for population stratification in multi-locus genome-wide association studies.

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作者： Rui,Liu ^[1] ; Min,Yuan ^[2] ; Xu Steven,Xu ^[3] ; Yaning,Yang ^[4]

作者单位： Department of Statistics and Finance, University of Science and Technology of China, Hefei, 230026, Anhui, China. ^[1] Center for Data Science in Health, School of Public Health Administration, Anhui Medical University, Hefei, 230032, Anhui, China. ^[2] Genmab US, Inc., Princeton, NJ, 08540, USA. ^[3] Department of Statistics and Finance, University of Science and Technology of China, Hefei, 230026, Anhui, China. ynyang@ustc.edu.cn. ^[4]

关键词 Correction for false discoveries LASSO Multi-marker Non-threshold Population stratification Principal component analysis Well-balanced selection

主题词阿尔茨海默病(Alzheimer Disease);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);基因组学(Genomics);人类(Humans);主成分分析(Principal Component Analysis);时间因素(Time Factors)

DOI 10.1007/s10709-021-00129-3

PMID 34480683

发布时间 2022-02-02

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