Improved Potency and Safety of DNA-Encoded Antibody Therapeutics Through Plasmid Backbone and Expression Cassette Engineering.

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第一作者： Giles,Vermeire

第一单位： Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven-University of Leuven, Leuven, Belgium.

作者： Giles,Vermeire ^[1] ; Elien,De Smidt ^[1] ; Nick,Geukens ^[2] ; James A,Williams ^[2] ; Paul,Declerck ^[3] ; Kevin,Hollevoet ^[1]

作者单位： Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven-University of Leuven, Leuven, Belgium. ^[1] PharmAbs, the KU Leuven Antibody Center-University of Leuven, Leuven, Belgium. ^[2] Nature Technology Corporation, Lincoln, Nebraska, USA. ^[3]

关键词 DNA engineering antibody gene transfer intramuscular electroporation minimal plasmids muscle-specific promoter

主题词动物(Animals);DNA(DNA);电穿孔(Electroporation);基因转移技术(Gene Transfer Techniques);小鼠(Mice);质粒(Plasmids);启动区, 遗传(Promoter Regions, Genetic)

DOI 10.1089/hum.2021.105

PMID 34482757

发布时间 2022-01-31

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准确一般字义偏差语意偏离译文作用小提交