Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis.

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作者： Kuniaki,Mukai ^[1] ; Hiroshi,Sugimoto ^[2] ; Katsumasa,Kamiya ^[3] ; Reiko,Suzuki ^[4] ; Tomomi,Matsuura ^[1] ; Takako,Hishiki ^[1] ; Hideo,Shimada ^[5] ; Yoshitsugu,Shiro ^[1] ; Makoto,Suematsu ^[5] ; Norio,Kagawa ^[1]

作者单位： Department of Biochemistry, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan. ^[1] Medical Education Center, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan. ^[2] Synchrotron Radiation Life Science Instrumentation Team, RIKEN SPring-8 Center, Sayo, Hyogo 679-5148, Japan. ^[3] Center for Basic Education and Integrated Learning, Kanagawa Institute of Technology, Atsugi, Kanagawa 243-0292, Japan. ^[4] Clinical and Translational Research Center, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan. ^[5] Graduate School of Life Science, University of Hyogo, Kamigori, Hyogo 678-1297, Japan. ^[6] Office of CIBoG, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan. ^[7]

关键词 Adrenal Cytochrome P450 DOC, 11-deoxycorticosterone DOF, 11-deoxycortisol Molecular dynamics Steroid hormone X-ray crystallography

DOI 10.1016/j.crstbi.2021.08.001

PMID 34485929

发布时间 2021-12-30

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Current research in structural biology

2021年3卷

192-205页

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Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis.

Current research in structural biology

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Current research in structural biology

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Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis.

Current research in structural biology

相似文献

Current research in structural biology

相关期刊

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