Cellular model system to dissect the isoform-selectivity of Akt inhibitors.-论文-万方医学网

第一作者： Lena,Quambusch

第一单位： Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.

作者： Lena,Quambusch ^[1] ; Laura,Depta ^[1] ; Ina,Landel ^[1] ; Melissa,Lubeck ^[1] ; Tonia,Kirschner ^[1] ; Jonas,Nabert ^[1] ; Niklas,Uhlenbrock ^[1] ; Jörn,Weisner ^[1] ; Michael,Kostka ^[2] ; Laura M,Levy ^[2] ; Carsten,Schultz-Fademrecht ^[3] ; Franziska,Glanemann ^[4] ; Kristina,Althoff ^[4] ; Matthias P,Müller ^[1] ; Jens T,Siveke ^[4] ; Daniel,Rauh ^[5]

作者单位： Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany. ^[1] Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Dortmund, Germany. ^[2] Lead Discovery Center GmbH, Dortmund, Germany. ^[3] Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Medicine Essen, Essen, Germany.;Division of Solid Tumor Translational Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), partner site Essen, Heidelberg, Germany. ^[4] Faculty of Chemistry and Chemical Biology, TU Dortmund University and Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany. daniel.rauh@tu-dortmund.de. ^[5]

医学主题词衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);别构调节(Allosteric Regulation);别构部位(Allosteric Site);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系(Cell Line);药物设计(Drug Design);基因表达(Gene Expression);HEK293细胞(HEK293 Cells);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);淋巴细胞(Lymphocytes);小鼠(Mice);丝裂原活化蛋白激酶1(Mitogen-Activated Protein Kinase 1);丝裂原活化蛋白激酶3(Mitogen-Activated Protein Kinase 3);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);重组蛋白质类(Recombinant Proteins);小分子化合物库(Small Molecule Libraries);斜纹夜蛾属(Spodoptera);构效关系(Structure-Activity Relationship)

DOI 10.1038/s41467-021-25512-8

PMID 34489430

发布时间 2023-02-05

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Cellular model system to dissect the isoform-selectivity of Akt inhibitors.

Nature communications

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Cellular model system to dissect the isoform-selectivity of Akt inhibitors.

Nature communications

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Nature communications

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