Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment.

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第一作者： Jie,Wang

第一单位： State Key Laboratory of Drug Research, Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.

作者： Jie,Wang ^[1] ; Wenhui,Wei ^[2] ; Xiaofei,Zhang ^[3] ; Shiqi,Cao ^[2] ; Bintao,Hu ^[1] ; Yang,Ye ^[3] ; Min,Jiang ^[2] ; Tianqi,Wang ^[2] ; Jianping,Zuo ^[4] ; Shijun,He ^[2] ; Chunhao,Yang ^[4]

作者单位： State Key Laboratory of Drug Research, Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China. ^[1] School of Pharmacy, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. ^[2] State Key Laboratory of Drug Research, Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China. ^[3] State Key Laboratory of Drug Research, Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[4] Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Second Ruijin Road, Shanghai 200025, China. ^[5]