Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance.
第一作者:
M Raymond V,Finlay
第一单位:
AstraZeneca, Oncology R&D, Research & Early Development, Darwin Building, 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
作者:
医学主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);人类(Humans);小鼠, 裸(Mice, Nude);小鼠, SCID(Mice, SCID);突变(Mutation);肿瘤(Neoplasms);有机磷化合物(Organophosphorus Compounds);蛋白激酶抑制剂(Protein Kinase Inhibitors);嘧啶类(Pyrimidines);大鼠(Rats);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);小鼠(Mice)
DOI
10.1021/acs.jmedchem.1c01055
PMID
34491761
发布时间
2024-02-26
- 浏览3
Journal of medicinal chemistry
13704-13718页
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