Development of MIF/IL-1β biosensors for discovery of critical quality attributes and potential allergic rhinitis targets from clinical real-world data by intelligent algorithm coupled with in vitro and vivo mechanism validation.

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作者： Lijuan,Ma ^[1] ; Yanfei,Zheng ^[2] ; Ji,Wang ^[2] ; Qianqian,Li ^[1] ; Jingqi,Zeng ^[1] ; Zijian,Wang ^[1] ; Tingjun,Hou ^[3] ; Yang,Zhang ^[4] ; Mingshuang,Li ^[1] ; Rongmin,Shen ^[2] ; Xuemei,Chen ^[2] ; Jingbo,Qin ^[2] ; Leting,Lei ^[1] ; Qing,Xia ^[5] ; Qi,Wang ^[6] ; Yanjiang,Qiao ^[7] ; Zhisheng,Wu ^[8]

作者单位： Beijing University of Chinese Medicine, School of Chinese Materia Medica, Beijing, 102488, China. ^[1] Beijing University of Chinese Medicine, School of Traditional Chinese Medicine, Beijing, 102488, China. ^[2] Zhejiang University, College of Pharmaceutical Sciences, Zhejiang, 310058, China. ^[3] Chinese Academy of Sciences, Institute of Semiconductors, Beijing, 100083, China. ^[4] Biology Institute of Shandong Academy of Sciences, Shandong, 250014, China. ^[5] Beijing University of Chinese Medicine, School of Traditional Chinese Medicine, Beijing, 102488, China; Pharmaceutical Engineering and New Drug Development of TCM of Ministry of Education, Beijing, 102488, China. Electronic address: wangqi710@126.com. ^[6] Beijing University of Chinese Medicine, School of Chinese Materia Medica, Beijing, 102488, China; Pharmaceutical Engineering and New Drug Development of TCM of Ministry of Education, Beijing, 102488, China. Electronic address: yjqiao@bucm.edu.cn. ^[7] Beijing University of Chinese Medicine, School of Chinese Materia Medica, Beijing, 102488, China; Pharmaceutical Engineering and New Drug Development of TCM of Ministry of Education, Beijing, 102488, China. Electronic address: wzs@bucm.edu.cn. ^[8]

关键词 Allergic rhinitis Clinical real-world data High electron mobility transistor biosensor Intelligent algorithm Interleukin-1β Macrophage migration inhibitory factor

主题词算法(Algorithms);生物传感技术(Biosensing Techniques);人类(Humans);白细胞介素1β(Interleukin-1beta);分子内氧化环原酶类(Intramolecular Oxidoreductases);巨噬细胞游走抑制因子(Macrophage Migration-Inhibitory Factors)

DOI 10.1016/j.bios.2021.113608

PMID 34500224

发布时间 2021-10-19

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