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Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.

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第一作者： Eric L,Harshfield

第一单位： British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. eh457@medschl.cam.ac.uk.;Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK. eh457@medschl.cam.ac.uk.

作者： Eric L,Harshfield ^[1] ; Eric B,Fauman ^[2] ; David,Stacey ^[3] ; Dirk S,Paul ^[4] ; Daniel,Ziemek ^[5] ; Rachel M Y,Ong ^[3] ; John,Danesh ^[4] ; Adam S,Butterworth ^[4] ; Asif,Rasheed ^[6] ; Taniya,Sattar ^[6] ; Zameer-Ul-Asar ^[6] ; Imran,Saleem ^[6] ; Zoubia,Hina ^[6] ; Unzila,Ishtiaq ^[6] ; Nadeem,Qamar ^[7] ; Nadeem Hayat,Mallick ^[8] ; Zia,Yaqub ^[7] ; Tahir,Saghir ^[7] ; Syed Nadeem Hasan,Rizvi ^[7] ; Anis,Memon ^[7] ; Mohammad,Ishaq ^[9] ; Syed Zahed,Rasheed ^[9] ; Fazal-Ur-Rehman,Memon ^[10] ; Anjum,Jalal ^[11] ; Shahid,Abbas ^[11] ; Philippe,Frossard ^[6] ; Danish,Saleheen ^[12] ; Angela M,Wood ^[4] ; Julian L,Griffin ^[13] ; Albert,Koulman ^[14]

作者单位： British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. eh457@medschl.cam.ac.uk.;Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK. eh457@medschl.cam.ac.uk. ^[1] Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, 02139, USA. ^[2] British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. ^[3] British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.;British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB2 0QQ, UK.;National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.;National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK.;Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, CB10 1SA, UK.;Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK. ^[4] Inflammation and Immunology, Pfizer Worldwide Research, Development and Medical, 10785, Berlin, Germany. ^[5] Center for Non-Communicable Diseases, Karachi, 75300, Pakistan. ^[6] National Institute of Cardiovascular Diseases, Karachi, 75510, Pakistan. ^[7] Punjab Institute of Cardiology, Lahore, 42000, Pakistan. ^[8] Karachi Institute of Heart Diseases, Karachi, 75950, Pakistan. ^[9] Red Crescent Institute of Cardiology, Hyderabad, 71500, Pakistan. ^[10] Faisalabad Institute of Cardiology, Faisalabad, 38000, Pakistan. ^[11] Center for Non-Communicable Diseases, Karachi, 75300, Pakistan.;Department of Biostatistics & Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA. ^[12] Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, CB2 1GA, UK. julian.griffin@imperial.ac.uk.;Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, SW7 2AZ, UK. julian.griffin@imperial.ac.uk. ^[13] Core Metabolomics and Lipidomics Laboratory, National Institute for Health Research, Cambridge Biomedical Research Centre, Cambridge, CB2 0QQ, UK. ak675@medschl.cam.ac.uk. ^[14]

关键词 Gaussian Graphical Modelling Genetics Lipidomics Network analysis South Asian

医学主题词疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);脂类(Lipids);心肌梗死(Myocardial Infarction);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1186/s12916-021-02087-1

PMID 34503513

发布时间 2025-05-30

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