Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer.

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第一作者： Rumi,Itoyama

第一单位： Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Gastrointestinal Cancer Biology, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan.

作者： Rumi,Itoyama ^[1] ; Noriko,Yasuda-Yoshihara ^[1] ; Fumimasa,Kitamura ^[1] ; Tadahito,Yasuda ^[1] ; Luke,Bu ^[1] ; Atsuko,Yonemura ^[1] ; Tomoyuki,Uchihara ^[1] ; Kota,Arima ^[1] ; Xichen,Hu ^[1] ; Zhang,Jun ^[1] ; Yuya,Okamoto ^[1] ; Takahiko,Akiyama ^[1] ; Kohei,Yamashita ^[2] ; Yosuke,Nakao ^[2] ; Toshihiko,Yusa ^[2] ; Yuki,Kitano ^[2] ; Takaaki,Higashi ^[2] ; Tatsunori,Miyata ^[2] ; Katsunori,Imai ^[2] ; Hiromitsu,Hayashi ^[2] ; Yo-Ichi,Yamashita ^[2] ; Takumi,Mikawa ^[3] ; Hiroshi,Kondoh ^[3] ; Hideo,Baba ^[4] ; Takatsugu,Ishimoto ^[5]

作者单位： Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Gastrointestinal Cancer Biology, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan. ^[1] Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. ^[2] Geriatric Unit, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan. ^[3] Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: hdobaba@kumamoto-u.ac.jp. ^[4] Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Gastrointestinal Cancer Biology, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan. Electronic address: taka1516@kumamoto-u.ac.jp. ^[5]

关键词 Cancer metabolism Glycolysis Nutrient microenvironment Pancreatic cancer Serine biosynthesis