Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer.
第一作者:
Rumi,Itoyama
第一单位:
Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Gastrointestinal Cancer Biology, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan.
作者:
主题词
动物(Animals);癌, 胰腺管(Carcinoma, Pancreatic Ductal);细胞系, 肿瘤(Cell Line, Tumor);CpG岛(CpG Islands);DNA甲基化(DNA Methylation);酶诱导(Enzyme Induction);甘油酸类(Glyceric Acids);人类(Humans);小鼠(Mice);胰腺肿瘤(Pancreatic Neoplasms);磷酸甘油脱氢酶(Phosphoglycerate Dehydrogenase);磷酸甘油酸酯变位酶(Phosphoglycerate Mutase);丝氨酸(Serine)
DOI
10.1016/j.canlet.2021.09.007
PMID
34508795
发布时间
2022-01-07
- 浏览0
Cancer letters
29-42页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文