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首页> BMJ open> IL-23 blockade with guselkumab potentially modifies psoriasis pathogenesis: rationale and study protocol of a phase 3b, randomised, double-blind, multicentre study in participants with moderate-to-severe plaque-type psoriasis (GUIDE).

IL-23 blockade with guselkumab potentially modifies psoriasis pathogenesis: rationale and study protocol of a phase 3b, randomised, double-blind, multicentre study in participants with moderate-to-severe plaque-type psoriasis (GUIDE).

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作者： Kilian,Eyerich ^[1] ; Peter,Weisenseel ^[2] ; Andreas,Pinter ^[3] ; Knut,Schäkel ^[4] ; Khusru,Asadullah ^[5] ; Sven,Wegner ^[6] ; Ernesto J,Muñoz-Elias ^[7] ; Holger,Bartz ^[8] ; Friedmann J H,Taut ^[9] ; Kristian,Reich ^[10]

作者单位： Department of Medicine, Division of Dermatology and Venereology, Karolinska Institute, Stockholm, Sweden. ^[1] Dermatologikum Hamburg GmbH, Hamburg, Germany. ^[2] University Hospital Frankfurt am Main, Frankfurt, Germany. ^[3] Department of Dermatology, and Interdisciplinary Center for Chronic Inflammatory Diseases, University Hospital Heidelberg, Heidelberg, Germany. ^[4] Dermatological Practice, Potsdam, Germany. ^[5] Janssen-Cilag GmbH, Neuss, Germany. ^[6] Janssen Research & Development, LLC, San Diego, California, USA. ^[7] Janssen-Cilag, Vienna, Austria. ^[8] TautScience and Service Ltd, Konstanz, Germany. ^[9] Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany kreich@jerucon.com. ^[10]

关键词 adult dermatology protocols & guidelines psoriasis

主题词抗体, 单克隆(Antibodies, Monoclonal);临床试验, Ⅲ期(主题)(Clinical Trials, Phase III as Topic);双盲法(Double-Blind Method);人类(Humans);白细胞介素23(Interleukin-23);多中心研究(主题)(Multicenter Studies as Topic);银屑病(Psoriasis);随机对照试验(主题)(Randomized Controlled Trials as Topic);疾病严重程度指数(Severity of Illness Index);治疗结果(Treatment Outcome)

DOI 10.1136/bmjopen-2021-049822

PMID 34518264

发布时间 2022-09-22

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BMJ open

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2021年11卷9期

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2021年11卷9期

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