首页> BMC genomic data> The choice of negative control antisense oligonucleotides dramatically impacts downstream analysis depending on the cellular background.

The choice of negative control antisense oligonucleotides dramatically impacts downstream analysis depending on the cellular background.

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第一作者： Luca,Ducoli

第一单位： Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.;Molecular Life Sciences PhD Program, Swiss Federal Institute of Technology and University of Zurich, Zurich, Switzerland.

作者： Luca,Ducoli ^[1] ; Saumya,Agrawal ^[2] ; Chung-Chau,Hon ^[2] ; Jordan A,Ramilowski ^[2] ; Eliane,Sibler ^[1] ; Michihira,Tagami ^[2] ; Masayoshi,Itoh ^[3] ; Naoto,Kondo ^[2] ; Imad,Abugessaisa ^[2] ; Akira,Hasegawa ^[2] ; Takeya,Kasukawa ^[2] ; Harukazu,Suzuki ^[2] ; Piero,Carninci ^[4] ; Jay W,Shin ^[2] ; Michiel J L,de Hoon ^[2] ; Michael,Detmar ^[5]

作者单位： Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.;Molecular Life Sciences PhD Program, Swiss Federal Institute of Technology and University of Zurich, Zurich, Switzerland. ^[1] RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.;RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan. ^[2] RIKEN Preventive Medicine and Diagnosis Innovation Program, RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan. ^[3] RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.;RIKEN Center for Life Science Technologies, Yokohama, Kanagawa, 230-0045, Japan.;Human Technopole, Via Cristina Belgioioso 171, 20157, Milan, Italy. ^[4] Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland. michael.detmar@pharma.ethz.ch. ^[5]

关键词 ASO Antisense oligonucleotide CAGE-Seq Cap analysis of gene expression Long noncoding RNA lncRNA

医学主题词成年人(Adult);内皮细胞(Endothelial Cells);基因敲低技术(Gene Knockdown Techniques);人类(Humans);淋巴系统(Lymphatic System);寡核苷酸类, 反义(Oligonucleotides, Antisense);器官特异性(Organ Specificity)

DOI 10.1186/s12863-021-00992-1

PMID 34521352

发布时间 2022-01-12

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准确一般字义偏差语意偏离译文作用小提交