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Oral delivery of proteins and peptides: Challenges, status quo and future perspectives.

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第一作者: Quangang,Zhu
第一单位: Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.
作者: Quangang,Zhu [1] ; Zhongjian,Chen [1] ; Pijush Kumar,Paul [2] ; Yi,Lu [3] ; Wei,Wu [3] ; Jianping,Qi [3]
作者单位: Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China. [1] Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.;Department of Pharmacy, Gono Bishwabidyalay (University), Mirzanagar Savar, Dhaka 1344, Bangladesh. [2] Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.;Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China. [3]
关键词 ASBT, apical sodium-dependent bile acid transporterBSA, bovine serum albuminCAGR, compound annual growthCD, Crohn's diseaseCOPD, chronic obstructive pulmonary diseaseCPP, cell penetrating peptideCaP, calcium phosphateClinicalDCs, dendritic cellsDDVAP, desmopressin acetateDTPA, diethylene triamine pentaacetic acidEDTA, ethylene diamine tetraacetic acidEPD, empirical phase diagramsEPR, electron paramagnetic resonanceEnzyme inhibitorFA, folic acidFDA, U.S. Food and Drug AdministrationFcRn, Fc receptorGALT, gut-associated lymphoid tissueGI, gastrointestinalGIPET, gastrointestinal permeation enhancement technologyGLP-1, glucagon-like peptide 1GRAS, generally recognized as safeHBsAg, hepatitis B surface antigenHPMCP, hydroxypropyl methylcellulose phthalateIBD, inflammatory bowel diseaseILs, ionic liquidsLBNs, lipid-based nanoparticlesLMWP, low molecular weight protamineMCT-1, monocarborxylate transporter 1MSNs, mesoporous silica nanoparticlesNAC, N-acetyl-l-cysteineNLCs, nanostructured lipid carriersOral deliveryPAA, polyacrylic acidPBPK, physiologically based pharmacokineticsPCA, principal component analysisPCL, polycarprolactonPGA, poly-γ-glutamic acidPLA, poly(latic acid)PLGA, poly(lactic-co-glycolic acid)PPs, proteins and peptidesPVA, poly vinyl alcoholPeptidesPermeation enhancerProteinsRGD, Arg-Gly-AspRTILs, room temperature ionic liquidsSAR, structure–activity relationshipSDC, sodium deoxycholateSGC, sodium glycocholateSGF, simulated gastric fluidsSIF, simulated intestinal fluidsSLNs, solid lipid nanoparticlesSNAC, sodium N-[8-(2-hydroxybenzoyl)amino]caprylateSNEDDS, self-nanoemulsifying drug delivery systemsSTC, sodium taurocholateStabilityTAT, trans-activating transcriptional peptideTMC, N-trimethyl chitosanTf, transferrinTfR, transferrin receptorsUC, ulcerative colitisUEA1, ulex europaeus agglutinin 1VB12, vitamin B12WGA, wheat germ agglutininpHPMA, N-(2-hydroxypropyl)methacrylamidepI, isoelectric pointsCT, salmon calcitoninsc, subcutaneous
DOI 10.1016/j.apsb.2021.04.001
PMID 34522593
发布时间 2024-04-03
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Acta pharmaceutica Sinica. B

Acta pharmaceutica Sinica. B

2021年11卷8期

2416-2448页

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