Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies.

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作者： Sonal V,Bhujbal ^[1] ; Biplob,Mitra ^[2] ; Uday,Jain ^[3] ; Yuchuan,Gong ^[2] ; Anjali,Agrawal ^[2] ; Shyam,Karki ^[2] ; Lynne S,Taylor ^[1] ; Sumit,Kumar ^[2] ; Qi,Tony Zhou ^[1]

作者单位： Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA. ^[1] Oral Product Development, Bristol Myers Squibb, Summit, NJ 07901, USA. ^[2] Material Science and Engineering, Bristol Myers Squibb, Summit, NJ 07901, USA. ^[3]

关键词 3DP, three-dimensional printing ASDs, amorphous solid dispersions ASES, aerosol solvent extraction system Amorphous solid dispersions CAP, cellulose acetate phthalate CO2, carbon dioxide CSG, continuous-spray granulation Co-precipitation Downstream processing Drug delivery EPAS, evaporative aqueous solution precipitation Eudragit?, polymethacrylates derivatives FDM, fused deposition modeling GAS, gas antisolvent HME, hot-melt extrusion HPC, hydroxypropyl cellulose HPMC, hydroxypropyl methylcellulose HPMCAS, hydroxypropyl methylcellulose acetate succinate HPMCP, hypromellose phthalate Manufacturing Melting process PCA, precipitation with compressed fluid antisolvent PGSS, precipitation from gas-saturated solutions PLGA, poly(lactic-co-glycolic acid PVP, polyvinylpyrrolidone PVPVA, polyvinylpyrrolidone/vinyl acetate RESS, rapid expansion of a supercritical solution SAS, supercritical antisolvent SCFs, supercritical fluids SEDS, solution-enhanced dispersion by SCF SLS, selective laser sintering Selection criteria Soluplus?, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer Solvent evaporation Stability Tg, glass transition temperature USC, ultrasound compaction scCO2, supercritical CO2

DOI 10.1016/j.apsb.2021.05.014

PMID 34522596

发布时间 2023-11-07

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Acta pharmaceutica Sinica. B

2021年11卷8期

2505-2536页

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Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies.

Acta pharmaceutica Sinica. B

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Acta pharmaceutica Sinica. B

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Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies.

Acta pharmaceutica Sinica. B

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Acta pharmaceutica Sinica. B

相关期刊

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