首页> Cell reports> Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment.

Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment.

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第一作者： Hridesh,Banerjee

第一单位： Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

作者： Hridesh,Banerjee ^[1] ; Hector,Nieves-Rosado ^[2] ; Aditi,Kulkarni ^[3] ; Benjamin,Murter ^[4] ; Kyle V,McGrath ^[1] ; Uma R,Chandran ^[5] ; Alexander,Chang ^[5] ; Andrea L,Szymczak-Workman ^[1] ; Lazar,Vujanovic ^[6] ; Greg M,Delgoffe ^[7] ; Robert L,Ferris ^[8] ; Lawrence P,Kane ^[9]

作者单位： Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ^[1] Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Graduate Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ^[2] Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ^[3] Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Graduate Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ^[4] Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ^[5] Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ^[6] Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ^[7] Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ^[8] Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: lkane@pitt.edu. ^[9]

关键词 T cell immunoglobulin and mucin 3 (Tim-3)cellular metabolism cellular signaling immunosuppression regulatory T cells (Treg)tumor immunology