Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4.

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作者： Nicholas,Trompeter ^[1] ; Joseph D,Gardinier ^[2] ; Victor,DeBarros ^[3] ; Mary,Boggs ^[3] ; Vimal,Gangadharan ^[3] ; William J,Cain ^[3] ; Lauren,Hurd ^[3] ; Randall L,Duncan ^[4]

作者单位： Biomedical Engineering, University of Delaware, Newark, DE, United States. ^[1] Biomechanics and Movement Science Program, University of Delaware, Newark, DE, United States; Bone and Joint Center, Henry Ford Hospital, Detroit, MI, United States. ^[2] Department of Biological Sciences, University of Delaware, Newark, DE, United States. ^[3] Biomedical Engineering, University of Delaware, Newark, DE, United States; Biomechanics and Movement Science Program, University of Delaware, Newark, DE, United States; Department of Biological Sciences, University of Delaware, Newark, DE, United States; Department of Biology, University of Michigan-Flint, Flint, MI, United States. Electronic address: duncanra@umich.edu. ^[4]

关键词 Actin Chondrocytes Hypotonic swelling IGF-1 Mechanosensitivity TRPV4

主题词软骨, 关节(Cartilage, Articular);细胞, 培养的(Cells, Cultured);软骨细胞(Chondrocytes);胰岛素样生长因子Ⅰ(Insulin-Like Growth Factor I);动力传导, 细胞(Mechanotransduction, Cellular);TRPV阳离子通道(TRPV Cation Channels)

DOI 10.1016/j.ceca.2021.102467

PMID 34530313

发布时间 2023-11-07

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